Jürg Bähler Selected Research

Genomic Instability

1/2021	R-loops and regulatory changes in chronologically ageing fission yeast cells drive non-random patterns of genome rearrangements.
1/2016	Increasing extracellular H2O2 produces a bi-phasic response in intracellular H2O2, with peroxiredoxin hyperoxidation only triggered once the cellular H2O2-buffering capacity is overwhelmed.
9/2014	A novel histone deacetylase complex in the control of transcription and genome stability.
5/2014	The DNA damage checkpoint pathway promotes extensive resection and nucleotide synthesis to facilitate homologous recombination repair and genome stability in fission yeast.
1/2011	CENP-B preserves genome integrity at replication forks paused by retrotransposon LTR.
12/2009	An acetylated form of histone H2A.Z regulates chromosome architecture in Schizosaccharomyces pombe.
8/2009	TOR complex 2 controls gene silencing, telomere length maintenance, and survival under DNA-damaging conditions.
2/2004	Global gene expression responses of fission yeast to ionizing radiation.

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Jürg Bähler Research Topics

Disease

9	Starvation 01/2023 - 01/2005
8	Genomic Instability 01/2021 - 02/2004
2	Neoplasms (Cancer) 01/2016 - 05/2014
1	Seizures (Absence Seizure) 01/2020
1	Ataxia (Dyssynergia) 01/2020
1	Infections 01/2020
1	Microcephaly 01/2020
1	Peripheral Nervous System Diseases (PNS Diseases) 01/2020
1	Inborn Genetic Diseases (Disease, Hereditary) 11/2017
1	Brain Diseases (Brain Disorder) 01/2017
1	Alzheimer Disease (Alzheimer's Disease) 01/2014
1	Hypersensitivity (Allergy) 02/2012
1	Mitochondrial Diseases (Mitochondrial Disease) 04/2011
1	Neurodegenerative Diseases (Neurodegenerative Disease) 04/2011
1	Oculocutaneous albinism type 2 07/2010
1	Iron Deficiencies 03/2008
1	Pseudohypoparathyroidism Type 2 03/2008
1	Werner Syndrome (Werner's Syndrome) 02/2005

Drug/Important Bio-Agent (IBA)

6	Proteins (Proteins, Gene)FDA Link 11/2017 - 02/2005
4	NitrogenIBA 01/2023 - 01/2005
3	Amino Acids FDA Link 01/2018 - 03/2008
3	DNA (Deoxyribonucleic Acid)IBA 05/2014 - 02/2004
2	Histone Deacetylases (Histone Deacetylase)IBA 09/2014 - 07/2010
2	IronIBA 04/2011 - 03/2008
2	Phosphotransferases (Kinase)IBA 11/2010 - 07/2010
2	Histidine (L-Histidine)FDA Link 11/2010 - 08/2008
2	Histones (Histone)IBA 07/2010 - 12/2009
1	Histone ChaperonesIBA 01/2023
1	Mitochondrial DNA (mtDNA)IBA 01/2021
1	RNA-Binding Proteins (RNA-Binding Protein)IBA 01/2021
1	asparaginyl-tRNA synthetaseIBA 01/2020
1	DNA-Directed RNA Polymerases (RNA Polymerase)IBA 01/2020
1	Transcription Factors (Transcription Factor)IBA 01/2018
1	Untranslated RNA (Noncoding RNA)IBA 11/2017
1	PrionsIBA 01/2017
1	PeroxidasesIBA 01/2016
1	PeroxiredoxinsIBA 01/2016
1	NucleotidesIBA 05/2014
1	LithiumIBA 01/2014
1	Mechanistic Target of Rapamycin Complex 1IBA 08/2013
1	Leucine (L-Leucine)FDA Link 02/2012
1	Sirolimus (Rapamycin)FDA Link 02/2012
1	CarbonIBA 04/2011
1	S pombe Sap1 proteinIBA 01/2011
1	AntioxidantsIBA 11/2010
1	Cysteine (L-Cysteine)FDA Link 11/2010
1	Protein Kinases (Protein Kinase)IBA 11/2010
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 07/2010
1	Amino Acid Transport Systems (Amino Acid Transporter)IBA 07/2010
1	Mechanistic Target of Rapamycin Complex 2IBA 08/2009
1	Activating Transcription Factor 1IBA 08/2008
1	CCAAT-Binding FactorIBA 03/2008
1	RecQ HelicasesIBA 02/2005